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Dash UC, Bhol NK, Swain SK et al (2024) Oxidative stress and inflammation in the pathogenesis of neurological disorders: mechanisms and implications

However, Epithalon remains investigational with no FDA approval, most research conducted in Russia with limited Western replication, long-term human safety data sparse, optimal dosing protocols still debated, and mechanisms not fully understood

Since pS10-H3 is a marker for chromosome condensation linked to mitosis, cellular stress (51) and DNA damage (52), its elevation in the triple drug combination likely reflects both a proliferation block and a stress response to vincristine