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Age-related increases in oxidative stress have been associated with chronic inflammation, cardiovascular and neurodegenerative disease, osteoarthritis and type 2 diabetes in humans (Reference Cannizzo, Clement and Sahu4Reference Rains and Jain6) and companion animals, namely cats (Reference Brown7,Reference Vite and Head8) and dogs (Reference Brown7Reference Pizzirani10)

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Those peptides were incubated with one stoichiometric equivalent with 100 M 13 C, 15 N-labeled FOXO4 FH