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Long term use of acid inhibitors causes numerous health problems contributing to such problems as osteoporosis and Alzheimers

"N-acetylcysteine: a safe antidote for cysteine/glutathione deficiency." Curr Opin Pharmacol

In theory, an increase in the cytosolic Ca 2+ concentration of an erythrocyte may be the consequence of Ca 2+ influx from the extracellular space, decreased Ca 2+ transport from the cytosol to the extracellular space, or release from intracellular Ca 2+ binders