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The primary cause of hyperpigmentation is an overproduction of melanin

[DOI] [PMC free article] [PubMed] [Google Scholar] 159.Loh K

While not directly sleep-related, systemic inflammation is a well-established disruptor of sleep quality Autoimmune myocarditis (FASEB J, 2017) -- attenuation of disease via Treg generation, further establishing anti-inflammatory potential Structure-activity studies (Nature Communications, 2021) -- investigation of analogs with improved selectivity, suggesting potential future clinical development No human studies have been conducted for cortistatin in any indication, including sleep

[3] BPC-157 is a synthetic peptide derived from a protective protein found in gastric juice