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3 Extended Administration Pharmacokinetics in DIO Mice Neelakantan et al., Biochemical Pharmacology (2024) This study reported a 28-day once-daily administration protocol of 5-Amino-1MQ in diet-induced obese mice, characterizing plasma pharmacokinetics, tissue distribution, and effects on body composition, fatty liver pathology, and circulating biomarkers

They deliver a high dose of B12 directly into the muscle (intramuscularly) or under the skin (subcutaneously)

Tirzepatide is typically administered once a week, while HCG injections are given daily or several times per week during a treatment cycle

Then, missing values were imputed from normal distribution by calculating width and center of the distribution