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One possible explanation is that the host environment resulting from a localized excitotoxic lesion differs fundamentally from that of a chronically degenerating brain burdened with aggregated proteins such as alpha-synuclein or huntingtin

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Endogenous APD is considered an autoimmune condition because someone who has APD reacts to progesterone when their immune system mistakenly identifies progesteronea hormone naturally produced by the body, with peak levels around day 21 of a 28-day menstrual cycle as a harmful substance

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