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Limited safety data on combinations in existing literature further emphasizes the need for cautious protocol design

Ginsenoside-Rg1 protects against renal fibrosis by regulating the klotho/TGF-1/smad signaling pathway in rats with obstructive nephropathy

Similarly, in periodontal tissues, it induces ferroptosis in fibroblasts by activating the HIF-1/p38 Mitogen-Activated Protein Kinase pathway and enhancing HIF-1/Cyclin-Dependent Kinase 9/ Bromodomain-Containing Protein 4 interactions, leading to NCOA4-mediated ferritinophagy (Zhao et al., 2020)