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This condition can damage hair follicles and impede melanin production, contributing to premature graying

The ASRM system does not correlate well with the symptoms of pain and dyspareunia or infertility

In line with this preclinical evidence, clinical studies have shown that bone-related hormones and BTM display circadian variations, while circadian rhythms disturbances such as working night shifts and/or sleeping disorders have been associated with impaired bone metabolism, reduced bone mass and increased fracture risk (Reference Swanson, Kohrt and Buxton20)

No drug-related serious adverse events occurred, and withdrawal rates due to adverse effects were comparable to placebo groups