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10,15,53 For example, human ER is homologous to ER, particularly in the DNA-binding domain (97% amino acid identity), but share little homology in the other domains (such as in the ligand-binding region), where one would predict that 17-estradiol would display different affinities for the ERs, but surprisingly, it has almost equal high affinity for ER and for ER

Possible reactions include stomach discomfort, bloating, abdominal cramping, nausea, loose stools, headache, skin rash, or an allergic response