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a surrogate marker of vascular health) in response to homocysteine reduction revealed that B-vitamin supplementation was accompanied by improved FMD in short-term ( 10.5 g/day) and breast cancer compared to the lowest quintile (4.3 g/day

Treating true deficiency can improve deficiency-related symptoms (including anemia-related fatigue and neurologic issues) (see the NIH ODS Vitamin B12 fact sheet )

From a translational medicine perspective, understanding the mechanisms of peptide pathway interactions can facilitate the development of rational drug combination strategies

Doses of pyridoxine as low as 5-10 mg can antagonize levodopas effect if carbidopa is not present, so caution is warranted and any supplemental B beyond the nutritional dose should be under medical guidance