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So, while the debate between localized and systemic application will likely continue, the most consistent and logically sound approach for targeted ankle research points toward a localized, subcutaneous injection near the site of injury

The end products of anaerobic metabolism are lactate and heat

Our experiments here in the whole heart corroborate the single-cell studies, given that diamide decreased total glutathione to a similar extent in both treatment groups, yet the 4-ClDzp-mediated protection was associated with much lower levels of GSSG