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AEDG peptide increased Nestin, GAP43, Tubulin III and Doublecortin mRNA expression by 1.61.8 times in hGMSCs

Metformin, the current first-line treatment in T2DM, has an unclear antidepressant effect [166] despite identified direct mechanisms and pleiotropic effects, including inhibition of angiotensin II and NF-B factor, normalization of gut microbiota, and intestinal permeabilization, and in vivo experimental data [167] supporting its potential benefits

See also: Beneficial regulation of fibrillar collagens by copper in dermal fibroblasts

Anisimov et al., 2001 Demonstrated antioxidant protection and normalization of circadian rhythm