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Note: Prolonged B12 deficiency can lead to permanent nerve damage

Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial

An RDP multicenter study from 2008 showed that Pycnogenol supplementation significantly reduced abdominal discomfort in women with dysmenorrhea ( for two menstrual cycles, during which they needed significantly less analgesic medication than in the registration period of two months before supplementation (46%) and less than placebo controls (28%)

Efflux regulators also respond to endogenous ligands (eg, AcrR responds to polyamines) to induce acrAB-tolC