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Limitations and outlook The heterogeneity of patients with RA is an important factor affecting the accuracy of the results of studies with small sample sizes (120)

Power calculations were conducted based on the approximation that the sample size for a MR study is the sample size for exposure on outcome divided by the r 2 for genetic proxies on exposure [38, 39]

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For example, thiazolidinediones, which inhibit ACSL4, can cause cardiac toxicity with prolonged use (Al Sultan et al., 2024), while zileuton, a lipoxygenase inhibitor, may lead to indigestion, nausea, and other issues